The chicken major histocompatibility complex and disease.

Identification and characterization of major histocompatibility complex class IIB alleles from three species of European ranid frogs

Immune genes of the major histocompatibility complex (MHC) are among the most polymorphic genes in the vertebrate genome. Due to their polymorphic nature, they are often used to assess the adaptive genetic variability of natural populations. This study describes the first molecular characterization of 13 partial MHC class IIB sequences from three European ranid frogs.  The utility of previously...

Simulation of Major Histocompatibility Complex (MHC) Structure and Peptide Loading into an MHC Binding Pocket with Teachers’Hands

Molecular understanding of three-dimensional (3D) peptide: MHC models require both basic knowledge of computational modeling and skilled visual perception, which are not possessed by all students. The present model aims to simulate MHC molecular structure with the hands and make a profound impression on the students.

A Case of Probable MHC Class II Deficiency with Disseminated BCGitis

Major histocompatibility complex (MHC) class II deficiency is a primary immunodeficiency disease characterized by abnormality of MHC class II molecules surface expression on peripheral blood lymphocytes and monocytes. Clinical manifestations include extreme susceptibility to viral, bacterial, and fungal infections but the immunodeficiency is not as severe as SCID (severe combined immunodeficien...

MMP3 -1171 5A/6A Promoter Polymorphism Affects Level of Serum Major Histocompatibility Complex Class Chain Related B in Breast Cancer Patients

Background and Aims: Involvement of matrix metalloproteinases 3 (MMP3) in breast cancer tumor progression and metastasis has been revealed. MMP3 -1171 5A/6A and 5A/5A polymorphisms in the gene  promoter increase expression of the enzyme. The possible relationship of these polymorphisms and serum levels of major histocompatibility complex class I chain-related protein A and B (MICA/B) in br...

Recombinants of the major histocompatibility complex in the chicken

Proceedings, 10 World Congress of Genetics Applied to Livestock Production Major Histocompatibility Complex Plays a Role in Survival Kinetics of Chicken Infected by Marek's Disease Virus

Chickens from a Brown Leghorn line were challenged with Marek’s Disease Virus (MDV). Mortality and all visceral and nerve lesions were daily recorded. Three Major Histocompatibility Complex (MHC) haplotypes were characterized using genetic markers from the MHC-B region. MHC had a significant effect on the kinetics of mortality from MDV, one genotype being associated with an earlier death. Survi...